Raina can`t wait to be a big sister, but once Amara is born she realizes things won`t be quite what she had expected...or hoped. Despite
Amara`s cuteness, she is a cranky, grouchy baby and mostly prefers to play by herself. Their relationship doesn`t improve much over the years but when a baby brother enters the picture and their parents` relationship starts to struggle, they realize they must figure out how to get along. They are sisters, after all.

Raina Telgemeier uses her signature humor and charm to tell the story of her relationship with her little sister, which unfolds during the course of a road trip from their home in San Francisco to a family reunion in Colorado.